An OGG1 activator
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TH10785

Item No. 43043

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-cyclohexyl-2-cyclopropyl-4-quinazolinamine
CAS Number
1002801-51-5
Molecular Formula
C17H21N3
Formula Weight
267.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Soluble: ≥ 10 mg/ml
SMILES
C1(NC2=NC(C3CC3)=NC4=C2C=CC=C4)CCCCC1
InChi Code
InChI=1S/C17H21N3/c1-2-6-13(7-3-1)18-17-14-8-4-5-9-15(14)19-16(20-17)12-10-11-12/h4-5,8-9,12-13H,1-3,6-7,10-11H2,(H,18,19,20)
InChi Key
ZQMGQZOHIDOPCQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    5 mg

    $72

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    10 mg

    $137

    Add

    25 mg

    $304

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    50 mg

    $572

    Add
    Product Description

    TH10785 is an 8-oxoguanine DNA glycosylase 1 (OGG1) activator.1 It increases OGG1-mediated excision of 8-oxoguanine (8-hydroxyguanine; Item No. 89290) in duplex oligonucleotides when used at a concentration of 10 µM. TH10785 (10, 30, or 100 µM) inhibits oxidative damage in A549 cells induced by paraquat (Item No. 38521). It reduces opacity and vacuole formation induced by hydrogen peroxide (H2O2) in primary rat lenses when used at a concentration of 10 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baptiste, B.A., Katchur, S.R., Fivenson, E.M., et al. Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention. Free Radic. Biol. Med. 124, 149-162 (2018).

    2. Geng, W., Li, P., Zhang, G., et al. Targeted activation of OGG1 inhibits paraptosis in lens epithelial cells of early age-related cortical cataract. Invest. Ophthalmol. Vis. Sci. 66(1), 29 (2025).