An NK1 receptor antagonist
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Lanepitant (hydrochloride)

Item No. 43044

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(R)-N-[2-[acetyl[(2-methoxyphenyl)methyl]amino]-1-(1H-indol-3-ylmethyl)ethyl]-[1,4′-bipiperidine]-1′-acetamide, dihydrochloride
CAS Number
170508-05-1
Synonyms
  • LY303870
Molecular Formula
C33H45N5O3 • 2HCl
Formula Weight
632.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlWater: Slightly soluble: 0.1-1 mg/ml
SMILES
CC(N(C[C@H](NC(CN1CCC(N2CCCCC2)CC1)=O)CC3=CNC4=CC=CC=C34)CC5=C(OC)C=CC=C5)=O.Cl.Cl
InChi Code
InChI=1S/C33H45N5O3.2ClH/c1-25(39)38(22-26-10-4-7-13-32(26)41-2)23-28(20-27-21-34-31-12-6-5-11-30(27)31)35-33(40)24-36-18-14-29(15-19-36)37-16-8-3-9-17-37;;/h4-7,10-13,21,28-29,34H,3,8-9,14-20,22-24H2,1-2H3,(H,35,40);2*1H/t28-;;/m1../s1
InChi Key
WURFRVBOVGQPHZ-QDSLRZTOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Lanepitant is a neurokinin-1 (NK1) receptor antagonist (Ki = 0.15 nM).1 It inhibits Ac-[Arg6,Sar9,Met(O2)11]-substance P6-11-induced increases in tail biting and scratching in mice when administered at doses of 1, 5, or 10 mg/kg. Lanepitant (10 mg/kg) inhibits late-phase formalin-induced increases in paw licking in mice. It reduces corneal opacity and neovascularization and decreases leukocyte infiltration in a mouse model of alkali burn-induced corneal damage when topically applied at a concentration of 6.4 mg/ml six times per day.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Iyengar, S., Hipskind, P.A., Gehlert, D.R., et al. LY303870, a centrally active neurokinin-1 antagonist with a long duration of action. J. Pharmacol. Exp. Ther. 280(2), 774-785 (1996).

    2. Bignami, F., Giacomini, C., Lorusso, A., et al. NK1 receptor antagonists as a new treatment for corneal neovascularization. Invest. Ophthalmol. Vis. Sci. 55(10), 6783-6794 (2014).