An active metabolite of pregnenolone
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

16-Dehydroprogesterone

Item No. 43057

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
pregna-4,16-diene-3,20-dione
CAS Number
1096-38-4
Synonyms
  • NSC 9785
  • NSC 11037
  • Δ16-Progesterone
Molecular Formula
C21H28O2
Formula Weight
312.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
C[C@@]12[C@]3([H])[C@](CCC1=CC(CC2)=O)([H])[C@@]4([H])[C@](CC3)(C(C(C)=O)=CC4)C
InChi Code
InChI=1S/C21H28O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h6,12,16,18-19H,4-5,7-11H2,1-3H3/t16-,18-,19-,20-,21+/m0/s1
InChi Key
VRRHHTISESGZFN-RKFFNLMFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $104

    Add

    10 mg

    $156

    Add

    25 mg

    $311

    Add

    50 mg

    $517

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    16-Dehydroprogesterone is a progestin and an active metabolite of pregnenolone (Item No. 19864).1,2,3 It inhibits the proliferation of HL-60 leukemia and U937 lymphoma cells (IC50s = 10.9 and 3.6 µM, respectively).2 16-Dehydroprogesterone (2 mg/kg), in combination with gonadotropin, increases ovary and uterine weights in prepuberal rhesus monkeys.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kwan, T.K., Taylor, N.F., and Gower, D.B. The use of steroid profiling in the resolution of pregnenolone metabolites from porcine testicular preparations. J. Chromatogr. 301(1), 189-197 (1984).

    2. Samudio, I., Konopleva, M., Safe, S., et al. Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure. Mol. Cancer Ther. 4(12), 1982-1992 (2005).

    3. Kar, A.B., and Chandra, H. Effect of some progestational steroids on the response of the ovary of prepuberal rhesus monkeys to exogenous gonadotrophin. Steroids 6(4), 463-472 (1965).