A 5-HT2A and dopamine D2 receptor antagonist
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AMI-193

Item No. 43100

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
CAS Number
510-74-7
Synonyms
  • Spiramide
Molecular Formula
C22H26FN3O2
Formula Weight
383.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
FC(C=C1)=CC=C1OCCCN2CCC(C3=O)(N(C4=CC=CC=C4)CN3)CC2
InChi Code
InChI=1S/C22H26FN3O2/c23-18-7-9-20(10-8-18)28-16-4-13-25-14-11-22(12-15-25)21(27)24-17-26(22)19-5-2-1-3-6-19/h1-3,5-10H,4,11-17H2,(H,24,27)
InChi Key
FJUKDAZEABGEIH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $80

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    10 mg

    $151

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    25 mg

    $317

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    50 mg

    $515

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    Product Description

    AMI-193 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT2A and the dopamine D2 receptor.1,2 It is selective for the 5-HT2A receptor over 5-HT2B and 5-HT1C receptors (Kis = 22.39, 977.24, and 1,548.82 nM, respectively) but does bind to the 5-HT1A receptor (Ki = 50 nM). It selectively binds to the dopamine D2 receptor over the dopamine D1 receptor (Kis = 3 and 2,530 nM, respectively).2 AMI-193 (0.05 mg/kg) completely inhibits amphetamine-induced increases in locomotor activity and rearing behavior in rats for at least three hours.3 It also reduces amphetamine-induced increases in locomotor activity and rearing behavior in mice when used at doses of 0.15 and 0.2 mg/kg but the effects only last for 30 minutes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Knight, A.R., Misra, A., Quirk, K., et al. Pharmacological characterisation of the agonist radioligand binding site of 5-HT2A, 5-HT2B and 5-HT2C receptors. Naunyn Schmiedebergs Arch. Pharmacol. 370(2), 114-123 (2004).

    2. Ismaiel, A.M., De Los Angeles, J., Teitler, M., et al. Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-HT2- versus 5-HT1C-selective antagonist. J. Med. Chem. 36(17), 2519-2525 (1993).

    3. Rolinski, Z., and Scheel-Krüger, J. The effect of dopamine and noradrenaline antagonists on amphetamine induced locomotor activity in mice and rats. Acta Pharmacol. Toxicol. (Copenh) 33(5), 385-399 (1973).