A CB2 receptor inverse agonist
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CB-65

Item No. 43106

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-chloro-N-cyclohexyl-1,4-dihydro-1-[2-(4-morpholinyl)ethyl]-4-oxo-3-quinolinecarboxamide
CAS Number
913534-05-1
Molecular Formula
C22H28ClN3O3
Formula Weight
417.9
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C1=CN(CCN2CCOCC2)C3=CC(Cl)=CC=C3C1=O)NC4CCCCC4
InChi Code
InChI=1S/C22H28ClN3O3/c23-16-6-7-18-20(14-16)26(9-8-25-10-12-29-13-11-25)15-19(21(18)27)22(28)24-17-4-2-1-3-5-17/h6-7,14-15,17H,1-5,8-13H2,(H,24,28)
InChi Key
MFKWLGOHFQBVAA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $153

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    10 mg

    $275

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    25 mg

    $651

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    50 mg

    $1,071

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    Cayman Chemical
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    Product Description

    CB-65 is a cannabinoid 2 (CB2) receptor inverse agonist.1 It selectively binds to CB2 over CB1 receptors (Kis = 3.3 nM and >1,000 nM, respectively) and increases forskolin-induced cAMP production in CHO cells expressing the human CB2 receptor (EC50 = 1.2 nM).1,2 CB-65 (0.625, 2.5, and 20 nM) inhibits HepG2 hepatocellular carcinoma (HCC) cell invasion in vitro.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Manera, C., Benetti, V., Castelli, M.P., et al. Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists. J. Med. Chem. 49(20), 5947-5957 (2006).

    2. Ndong, C., O'Donnell, D., Ahmad, S., et al. Cloning and pharmacological characterization of the dog cannabinoid CB2 receptor. Eur. J. Pharmacol. 669(1-3), 24-31 (2011).

    3. Pourkhalili, N., Ghahremani, M.H., Farsandaj, N., et al. Evaluation of anti-invasion effect of cannabinoids on human hepatocarcinoma cells. Toxicol. Mech. Methods 23(2), 120-126 (2013).