A TYK2 inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

TC JL 37

Item No. 43110

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-4-cyano-6-fluoro-N-[2-[[[(1R,2R)-2-fluorocyclopropyl]carbonyl]amino]-4-pyridinyl]-benzamide
CAS Number
1258294-34-6
Molecular Formula
C17H11ClF2N4O2
Formula Weight
376.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(C1=C(C=C(C=C1F)C#N)Cl)NC2=CC=NC(NC([C@@H]3[C@@H](C3)F)=O)=C2
InChi Code
InChI=1S/C17H11ClF2N4O2/c18-11-3-8(7-21)4-13(20)15(11)17(26)23-9-1-2-22-14(5-9)24-16(25)10-6-12(10)19/h1-5,10,12H,6H2,(H2,22,23,24,25,26)/t10-,12+/m0/s1
InChi Key
NKALKXMQBFLGQI-CMPLNLGQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    1 mg

    $31

    Add

    5 mg

    $139

    Add

    10 mg

    $216

    Add

    25 mg

    $539

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    TC JL 37 is an inhibitor of tyrosine kinase 2 (TYK2; Ki = 1.6 nM).1 It inhibits IL-12-induced phosphorylation of STAT4 in cells and IL-12- and IL-18-induced IFN-γ production in isolated human peripheral blood mononuclear cells (PBMCs; EC50s = 224 and 168 nM, respectively). TC JL 37 (10-100 mg/kg) inhibits IL-12- and IL-18-induced increases in the serum levels of IFN-γ in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liang, J., van Abbema, A., Balazs, M., et al. Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors. J. Med. Chem. 56(11), 4521-4536 (2013).