A positive allosteric modulator of mGluR7 and mGluR8
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

VU6005649

Item No. 43138

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine
CAS Number
2137047-43-7
Molecular Formula
C16H12F5N3O
Formula Weight
357.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
FC1=C(C(C2=C3N=C(C)C=C(C(F)(F)F)N3N=C2C)=CC=C1OC)F
InChi Code
InChI=1S/C16H12F5N3O/c1-7-6-11(16(19,20)21)24-15(22-7)12(8(2)23-24)9-4-5-10(25-3)14(18)13(9)17/h4-6H,1-3H3
InChi Key
NYBZCKAQIIPSDS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $76

    Add

    10 mg

    $121

    Add

    25 mg

    $228

    Add

    50 mg

    $380

    Add
    Product Description

    VU6005649 is a positive allosteric modulator (PAM) of metabotropic glutamate receptor 7 (mGluR7) and mGluR8.1 It enhances calcium mobilization induced by L-AP4 (Item No. 14538) in HEK cells expressing mGluR7 or mGluR8 (EC50s = 0.65 and 2.6 µM, respectively). It is selective for mGluR7 and mGluR8 over mGluR1-6, as well as a panel of 67 GPCRs, ion channels, transports, and nuclear hormone receptors, at 10 µM but does inhibit the neurokinin-1 (NK1) receptor (IC50 = 3.4 µM). In vivo, VU6005649 (50 mg/kg, i.p) increases the length of freezing time induced by contextual fear conditioning in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Abe, M., Seto, M., Gogliotti, R.G., et al. Discovery of VU6005649, a CNS penetrant mGlu7/8 receptor PAM derived from a series of pyrazolo[1,5- a]pyrimidines. ACS Med. Chem. Lett. 8(10), 1110-1115 (2017).