A RARβ2 agonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

AC-55649

Item No. 43166

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4′-octyl-[1,1′-biphenyl]-4-carboxylic acid
CAS Number
59662-49-6
Molecular Formula
C21H26O2
Formula Weight
310.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlChloroform: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C1=CC=C(C2=CC=C(CCCCCCCC)C=C2)C=C1)O
InChi Code
InChI=1S/C21H26O2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)19-13-15-20(16-14-19)21(22)23/h9-16H,2-8H2,1H3,(H,22,23)
InChi Key
HXBKPYIEQLLNBK-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $61

    Add

    10 mg

    $109

    Add

    25 mg

    $197

    Add

    50 mg

    $363

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    AC-55649 is a retinoic acid receptor β2 (RARβ2) agonist.1 It selectively induces RARβ2 activity over RARα, RARβ1, and RARγ activity in functional assays using NIH3T3 cells (EC50s = 126, 2,512, 1,995, and 6,310 nM, respectively).2 AC-55649 reduces the proliferation of MCF-7 breast cancer cells in a concentration-dependent manner and induces neurite outgrowth in retinoid-responsive NTERA-2 cells when used at a concentration of 10 µM. It reduces fasting blood glucose levels in mice fed a high-fat diet as a model of type 2 diabetes.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lund, B.W., Piu, F., Gauthier, N.K., et al. Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist. J. Med. Chem. 48(24), 7517-7519 (2005).

    2. Piu, F., Gauthier, N.K., Olsson, R., et al. Identification of novel subtype selective RAR agonists. Biochem. Pharmacol. 71(1-2), 156-162 (2025).

    3. Trasino, S.E., Tang, X.H., Jessurun, J., et al. Retinoic acid receptor β2 agonists restore glycaemic control in diabetes and reduce steatosis. Diabetes Obes. Metab. 18(2), 142-151 (2016).