A RARβ2 agonist
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AC-55649

Item No. 43166

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4′-octyl-[1,1′-biphenyl]-4-carboxylic acid
CAS Number
59662-49-6
Molecular Formula
C21H26O2
Formula Weight
310.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlChloroform: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C1=CC=C(C2=CC=C(CCCCCCCC)C=C2)C=C1)O
InChi Code
InChI=1S/C21H26O2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)19-13-15-20(16-14-19)21(22)23/h9-16H,2-8H2,1H3,(H,22,23)
InChi Key
HXBKPYIEQLLNBK-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $61

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    10 mg

    $109

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    25 mg

    $197

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    50 mg

    $363

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    AC-55649 is a retinoic acid receptor β2 (RARβ2) agonist.1 It selectively induces RARβ2 activity over RARα, RARβ1, and RARγ activity in functional assays using NIH3T3 cells (EC50s = 126, 2,512, 1,995, and 6,310 nM, respectively).2 AC-55649 reduces the proliferation of MCF-7 breast cancer cells in a concentration-dependent manner and induces neurite outgrowth in retinoid-responsive NTERA-2 cells when used at a concentration of 10 µM. It reduces fasting blood glucose levels in mice fed a high-fat diet as a model of type 2 diabetes.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lund, B.W., Piu, F., Gauthier, N.K., et al. Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist. J. Med. Chem. 48(24), 7517-7519 (2005).

    2. Piu, F., Gauthier, N.K., Olsson, R., et al. Identification of novel subtype selective RAR agonists. Biochem. Pharmacol. 71(1-2), 156-162 (2025).

    3. Trasino, S.E., Tang, X.H., Jessurun, J., et al. Retinoic acid receptor β2 agonists restore glycaemic control in diabetes and reduce steatosis. Diabetes Obes. Metab. 18(2), 142-151 (2016).