A partial agonist of PPARγ
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INT-131

Item No. 43167

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4-dichloro-N-[3,5-dichloro-4-(3-quinolinyloxy)phenyl]-benzenesulfonamide
CAS Number
315224-26-1
Synonyms
  • AMG 131
Molecular Formula
C21H12Cl4N2O3S
Formula Weight
514.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=S(NC1=CC(Cl)=C(C(Cl)=C1)OC2=CN=C3C=CC=CC3=C2)(C4=CC=C(Cl)C=C4Cl)=O
InChi Code
InChI=1S/C21H12Cl4N2O3S/c22-13-5-6-20(16(23)8-13)31(28,29)27-14-9-17(24)21(18(25)10-14)30-15-7-12-3-1-2-4-19(12)26-11-15/h1-11,27H
InChi Key
NMRWDFUZLLQSBN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    50 mg

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    INT-131 is a partial agonist of peroxisome proliferator-activated receptor γ (PPARγ).1 It binds to PPARγ (IC50 = 0.017 µM) and induces PPARγ transactivation in HEK293 cells expressing the human receptor (EC50 = 0.15 µM). INT-131 (30 mg/kg) reduces blood glucose and insulin levels in KKAy diabetic mice. It reduces brain levels of TNF-α, IL-1β, chemokine (C-C motif) ligand 3 (CCL3), and complement C3 in a mouse model of ecotropic HIV-1 infection.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Taygerly, J.P., McGee, L.R., Rubenstein, S.M., et al. Discovery of INT131: A selective PPARγ modulator that enhances insulin sensitivity. Bioorg. Med. Chem. 21(4), 979-992 (2013).

    2. Omeragic, A., Saikali, M.F., Currier, S., et al. Selective peroxisome proliferator-activated receptor-gamma modulator, INT131 exhibits anti-inflammatory effects in an EcoHIV mouse model. FASEB J. 34(2), 1996-2010 (2020).