An α1-AR antagonist
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2-PMDQ

Item No. 43206

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,6-dihydro-2-[(4-phenyl-1-piperazinyl)methyl]-imidazo[1,2-c]quinazolin-5(3H)-one
CAS Number
139047-55-5
Synonyms
  • AT-112
Molecular Formula
C21H23N5O
Formula Weight
361.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C1NC2=C(C3=NC(CN4CCN(CC4)C5=CC=CC=C5)CN13)C=CC=C2
InChi Code
InChI=1S/C21H23N5O/c27-21-23-19-9-5-4-8-18(19)20-22-16(15-26(20)21)14-24-10-12-25(13-11-24)17-6-2-1-3-7-17/h1-9,16H,10-15H2,(H,23,27)
InChi Key
ONSOQRPYFKDOEB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

    $164

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    10 mg

    $290

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    25 mg

    $578

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    Product Description

    2-PMDQ is an antagonist of α1-adrenergic receptors (α1-ARs; Ki = 1.7 nM).1 It is selective for α1-ARs over α2-ARs (Ki = 962 nM). 2-PMDQ has antihypertensive activity in anesthetized rats (ED50 = 0.25 mg/kg).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chern, J.W., Tao, P.L., Yen, M.H., et al. Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: A novel class of potent and selective α1-adrenoceptor antagonists and antihypertensive agents. J. Med. Chem. 36(15), 2196-2207 (1993).

    2. Chern, J.-W., Shiau, C.-Y., and Lu, G.-Y. Studies on quinazolinones. 3: 1 novel and efficient route to the synthesis of conformationally restricted analogues of ketanserin and SGB-1534 as antihypertensive agents. Bioorg. Med. Chem. Lett. 1(11), 571-574 (1991).