An androgen receptor antagonist
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LY2452473

Item No. 43312

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(2S)-7-cyano-1,2,3,4-tetrahydro-4-(2-pyridinylmethyl)cyclopent[b]indol-2-yl]-carbamic acid, 1-methylethyl ester
CAS Number
1029692-15-6
Synonyms
  • TT 701
Molecular Formula
C22H22N4O2
Formula Weight
374.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
N#CC1=CC=C(N(C2=C3C[C@@H](C2)NC(OC(C)C)=O)CC4=CC=CC=N4)C3=C1
InChi Code
InChI=1S/C22H22N4O2/c1-14(2)28-22(27)25-17-10-19-18-9-15(12-23)6-7-20(18)26(21(19)11-17)13-16-5-3-4-8-24-16/h3-9,14,17H,10-11,13H2,1-2H3,(H,25,27)/t17-/m0/s1
InChi Key
IHIWYQYVBNODSV-KRWDZBQOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $87

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    10 mg

    $139

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    25 mg

    $218

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    50 mg

    $261

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    Product Description

    LY2452473 is an androgen receptor antagonist (IC50 = 8.565 nM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Popović, L., Brankatschk, B., Palladino, G., et al. Polypharmacological profiling across protein target families and cellular pathways using the multiplexed cell-based assay platform safetyProfiler reveals efficacy, potency and side effects of drugs. Biomed. Pharmacother. 180, 117523 (2024).