A Rheb inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Rheb Inhibitor NR1

Item No. 43360

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-bromo-6-[(3,4-dichlorophenyl)thio]-1-[[4-[(dimethylamino)carbonyl]phenyl]methyl]-1H-indole-2-carboxylic acid
CAS Number
2216763-38-9
Molecular Formula
C25H19BrCl2N2O3S
Formula Weight
578.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C1=CC2=C(N1CC3=CC=C(C(N(C)C)=O)C=C3)C=C(SC4=CC=C(C(Cl)=C4)Cl)C=C2Br)O
InChi Code
InChI=1S/C25H19BrCl2N2O3S/c1-29(2)24(31)15-5-3-14(4-6-15)13-30-22-11-17(34-16-7-8-20(27)21(28)10-16)9-19(26)18(22)12-23(30)25(32)33/h3-12H,13H2,1-2H3,(H,32,33)
InChi Key
MJYFVDNMTKLGTH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $52

    Add

    5 mg

    $246

    Add

    10 mg

    $440

    Add

    25 mg

    $906

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    Rheb inhibitor NR1 is an inhibitor of Ras homolog enriched in brain (Rheb).1 It inhibits Rheb-dependent mTORC1 activity (IC50 = 2.1 µM). It selectively inhibits Rheb-depedent mTORC1 activity over Rheb-independent mTORC1 activity, mTORC2, Ras, and Rap1 at 30 µM. Rheb inhibitor NR1 (10 µM) decreases the size of Jurkat T cells and inhibits protein synthesis in MCF-7 breast cancer cells. In vivo, Rheb inhibitor NR1 (30 mg/kg) inhibits the phosphorylation of the mTORC1 substrates S6 and 4E-BP1 in mouse skeletal muscle and kidneys.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mahoney, S.J., Narayan, S., Molz, L., et al. A small molecule inhibitor of Rheb selectively targets mTORC1 signaling. Nat. Commun. 9(1), 548 (2018).