An anorexigenic peptide
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BRINP2-related Peptide

Item No. 43361

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-threonyl-L-histidyl-L-arginyl-L-isoleucyl-L-leucyl-L-arginyl-L-arginyl-L-leucyl-L-phenylalanyl-L-asparaginyl-L-leucyl-L-cysteinamide
Synonyms
  • BRP
Molecular Formula
C68H117N25O14S
Formula Weight
1540.9
Formulation (Request formulation change)
A lyophilized peptide in trifluoroacetate salt
Peptide Sequence
THRILRRLFNLC-NH2
Storage Buffer
Soluble in water or phosphate buffer up to 30 mg/ml
SMILES
[H]N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CS)=O)=O)=O)CC1=CC=CC=C1)=O)=O)=O)=O)=O)=O)=O)CC2=CN=CN2)=O
InChi Code
InChI=1S/C68H117N25O14S/c1-10-37(8)53(93-57(99)43(21-16-24-81-68(76)77)85-62(104)48(29-40-31-78-33-82-40)90-64(106)52(70)38(9)94)65(107)91-46(27-36(6)7)58(100)84-41(19-14-22-79-66(72)73)55(97)83-42(20-15-23-80-67(74)75)56(98)86-44(25-34(2)3)59(101)88-47(28-39-17-12-11-13-18-39)61(103)89-49(30-51(69)95)63(105)87-45(26-35(4)5)60(102)92-50(32-108)54(71)96/h11-13,17-18,31,33-38,41-50,52-53,94,108H,10,14-16,19-30,32,70H2,1-9H3,(H2,69,95)(H2,71,96)(H,78,82)(H,83,97)(H,84,100)(H,85,104)(H,86,98)(H,87,105)(H,88,101)(H,89,103)(H,90,106)(H,91,107)(H,92,102)(H,93,99)(H4,72,73,79)(H4,74,75,80)(H4,76,77,81)/t37-,38+,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,52-,53-/m0/s1
InChi Key
HMJIRJDBVYKLDC-KVBBLKIJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $219

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    5 mg

    $876

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    BRINP2-related peptide is an anorexigenic peptide.1 It is formed from BRINP2 via cleavage by proconvertases and is expressed in the brain and cerebrospinal fluid (CSF). In vivo, BRINP2-related peptide (5 mg/kg) reduces food intake and increases the time between meals in mice. It reduces fasting glucose and insulin levels, subcutaneous white adipose tissue (WAT), brown adipose tissue (BAT), liver mass, and body weight without reducing lean mass in a mouse model of high-fat diet-induced obesity and diabetes, independent of the glucagon-like peptide 1 receptor (GLP-1R), leptin, or melanocortin receptor 4 (MC4R). Intracerebroventricular administration of BRINP2-related peptide (0.5 mg/kg) reduces food intake and increases Fos expression in the dorsomedial hypothalamic nucleus, preoptic hypothalamic nucleus, tuberal nucleus, and arcuate nucleus, but not the hindbrain or brainstem, in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Coassolo, L., Danneskiold-Samsøe, N.B., Nguyen, Q., et al. Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide. Nature 641(8061), 192-201 (2025).