A MAP3K8 inhibitor
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Cot Inhibitor 1

Item No. 43368

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-[2-(hexahydro-1H-azepin-1-yl)ethyl]-1H-1,2,3-triazol-4-yl]methyl]amino]-3-quinolinecarbonitrile
CAS Number
915365-57-0
Molecular Formula
C27H27Cl2FN8
Formula Weight
553.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/ml
SMILES
N#CC1=CN=C2C(Cl)=CC(NCC3=CN(CCN4CCCCCC4)N=N3)=CC2=C1NC5=CC=C(F)C(Cl)=C5
InChi Code
InChI=1S/C27H27Cl2FN8/c28-23-12-19(5-6-25(23)30)34-26-18(14-31)15-33-27-22(26)11-20(13-24(27)29)32-16-21-17-38(36-35-21)10-9-37-7-3-1-2-4-8-37/h5-6,11-13,15,17,32H,1-4,7-10,16H2,(H,33,34)
InChi Key
ZWFKJFUFYPOTKL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $71

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    5 mg

    $229

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    10 mg

    $352

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    25 mg

    $616

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    Product Description

    Cot inhibitor 1 is an inhibitor of MAP3K8 (IC50 = 28 nM).1 It inhibits LPS-induced increases in TNF-α levels in isolated human whole blood (IC50 = 5.4 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wu, J., Green, N., Hotchandani, R., et al. Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-α production in human whole blood. Bioorg. Med. Chem. Lett. 19(13), 3485-3488 (2009).