A mycotoxin
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Roridin A

Item No. 43401

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7′R-deoxo-7′-[(1R)-1-hydroxyethyl]-verrucarin A
CAS Number
14729-29-4
Molecular Formula
C29H40O9
Formula Weight
532.6
Purity
≥70%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Dichloromethane: SolubleDMSO: SolubleEthanol: SolubleMethanol: Soluble
SMILES
O[C@H](C(OC1)=O)[C@H](C)CCO[C@]([C@H](O)C)([H])/C=C/C=C\C(O[C@H]2[C@]3(C)[C@@]41CCC(C)=C[C@@]4([H])O[C@@](C2)([H])[C@]35OC5)=O
InChi Code
InChI=1S/C29H40O9/c1-17-9-11-28-15-35-26(33)25(32)18(2)10-12-34-20(19(3)30)7-5-6-8-24(31)38-21-14-23(37-22(28)13-17)29(16-36-29)27(21,28)4/h5-8,13,18-23,25,30,32H,9-12,14-16H2,1-4H3/b7-5+,8-6-/t18-,19-,20-,21-,22-,23-,25+,27-,28-,29+/m1/s1
InChi Key
NSFWWJIQIKBZMJ-PAGWOCKZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $263

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    Product Description

    Roridin A is a mycotoxin that has been found in M. verrucaria.1,2,3,4 It reduces the growth of P. falciparum (EC50 = 0.31 ng/ml).1 Roridin A (2.3, 3.9, or 4.1 mg/kg) is toxic to rabbits.4 It has been found in agricultural soil samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Isaka, M., Punya, J., Lertwerawat, Y., et al. Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria. J. Nat. Prod. 62(2), 329-331 (1999).

    2. Nguyen, M.V., Han, J.W., Kim, H., et al. Curvicollide D, a new modified γ-lactone from the culture broth of Albifimbria verrucaria and its antifungal activity against plant pathogenic fungi. J. Antibiot. (Tokyo) 75(9), 514-518 (2022).

    3. Nguyen, L.T.T., Jang, J.Y., Kim, T.Y., et al. Nematicidal activity of verrucarin A and roridin A isolated from Myrothecium verrucaria against Meloidogyne incognita. Pestic. Biochem. Physiol. 148, 133-143 (2018).

    4. Habermehl, G.G., Busam, L., Heydel, P., et al. Macrocyclic trichothecenes: Cause of livestock poisoning by the Brazilian plant Baccharis coridifolia. Toxicon. 23(5), 731-745 (1985).