An FFAR1/GPR40 agonist
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AM4668

Item No. 43419

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
βS-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]phenyl]-3-isoxazolepropanoic acid
CAS Number
1011531-27-3
Molecular Formula
C24H19F3N2O4S
Formula Weight
488.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
OC(C[C@@H](C1=CC=C(OCC2=C(C)N=C(C3=CC=C(C(F)(F)F)C=C3)S2)C=C1)C4=NOC=C4)=O
InChi Code
InChI=1S/C24H19F3N2O4S/c1-14-21(34-23(28-14)16-2-6-17(7-3-16)24(25,26)27)13-32-18-8-4-15(5-9-18)19(12-22(30)31)20-10-11-33-29-20/h2-11,19H,12-13H2,1H3,(H,30,31)/t19-/m0/s1
InChi Key
BMLGZNVPWRUVNM-IBGZPJMESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $108

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    1 mg

    $205

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    5 mg

    $917

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    AM4668 is an agonist of free fatty acid receptor 1 (FFAR1/GPR40).1 It induces inositol-1,4,5-triphosphate (IP3) production in A9 cells expressing human FFAR1/GPR40 (EC50 = 3.6 nM). AM4668 induces insulin secretion from pancreatic islets isolated from FFAR1 knock-in mice. In vivo, AM4668 (10 mg/kg) reduces blood glucose levels in FFAR1 knock-in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, J.J., Wang, Y., Ma, Z., et al. Optimization of GPR40 agonists for type 2 diabetes. ACS Med. Chem. Lett. 5(5), 517-521 (2014).