An FFAR1/GPR40 agonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

AM4668

Item No. 43419

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
βS-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]phenyl]-3-isoxazolepropanoic acid
CAS Number
1011531-27-3
Molecular Formula
C24H19F3N2O4S
Formula Weight
488.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
OC(C[C@@H](C1=CC=C(OCC2=C(C)N=C(C3=CC=C(C(F)(F)F)C=C3)S2)C=C1)C4=NOC=C4)=O
InChi Code
InChI=1S/C24H19F3N2O4S/c1-14-21(34-23(28-14)16-2-6-17(7-3-16)24(25,26)27)13-32-18-8-4-15(5-9-18)19(12-22(30)31)20-10-11-33-29-20/h2-11,19H,12-13H2,1H3,(H,30,31)/t19-/m0/s1
InChi Key
BMLGZNVPWRUVNM-IBGZPJMESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $108

    Add

    1 mg

    $205

    Add

    5 mg

    $917

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    AM4668 is an agonist of free fatty acid receptor 1 (FFAR1/GPR40).1 It induces inositol-1,4,5-triphosphate (IP3) production in A9 cells expressing human FFAR1/GPR40 (EC50 = 3.6 nM). AM4668 induces insulin secretion from pancreatic islets isolated from FFAR1 knock-in mice. In vivo, AM4668 (10 mg/kg) reduces blood glucose levels in FFAR1 knock-in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, J.J., Wang, Y., Ma, Z., et al. Optimization of GPR40 agonists for type 2 diabetes. ACS Med. Chem. Lett. 5(5), 517-521 (2014).