An inhibitor of Src kinase
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K882

Item No. 43422

Product Insert (PDF)
Technical Information
Formal Name
(E)-4-(2,5-dimethoxystyryl)quinazoline
Molecular Formula
C18H16N2O2
Formula Weight
292.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
COC1=CC(/C=C/C2=NC=NC3=CC=CC=C23)=C(OC)C=C1
InChi Code
InChI=1S/C18H16N2O2/c1-21-14-8-10-18(22-2)13(11-14)7-9-17-15-5-3-4-6-16(15)19-12-20-17/h3-12H,1-2H3/b9-7+
InChi Key
BZIBNGDUNNRTCZ-VQHVLOKHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $160

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    10 mg

    $300

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    25 mg

    $660

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    Product Description

    K882 is an inhibitor of Src kinase.1 It binds to Src (Kd = 315 nM), decreases phosphorylation at the tyrosine in position 416 (Y416), a Src activation site, and increases phosphorylation at Y527, an inactivation site. K882 reduces the proliferation of wild-type NCI H358 non-small cell lung cancer cells and NCI H358 cells expressing a KRASG12C mutation (IC50s = 2.14 and 2.03 µM, respectively). It also inhibits migration and invasion of NCI H358 cells when used at concentrations of 2, 4, and 8 µM, induces cell cycle arrest in the G2/M phase at 1, 4, and 8 µM, and induces apoptosis at 4 and 8 µM. K882 (25, 50, and 100 mg/kg) reduces tumor volume in an NCI H358 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ma, X., Ma, Z., Qi, X., et al. Identification of a novel Src inhibitor K882 derived from quinazoline-based stilbenes with anti-NSCLC effect. Bioorg. Chem. 156, 108185 (2025).