A Piezo1 agonist
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Yaddle1

Item No. 43431

Product Insert (PDF)
Technical Information
Formal Name
2-[5-[[[2-chloro-6-(trifluoromethyl)phenyl]methyl]thio]-1,3,4-oxadiazol-2-yl]-pyrazine
CAS Number
3041134-13-5
Molecular Formula
C14H8ClF3N4OS
Formula Weight
372.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
ClC1=C(CSC2=NN=C(C3=CN=CC=N3)O2)C(C(F)(F)F)=CC=C1
InChi Code
InChI=1S/C14H8ClF3N4OS/c15-10-3-1-2-9(14(16,17)18)8(10)7-24-13-22-21-12(23-13)11-6-19-4-5-20-11/h1-6H,7H2
InChi Key
CFUNYUCUSGNBPX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $119

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    10 mg

    $226

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    25 mg

    $476

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    Cayman Chemical
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    Product Description

    Yaddle1 is an agonist of Piezo1 and a derivative of Yoda1 (Item No. 21904).1 It induces calcium influx in a reporter assay using HEK293A cells expressing human Piezo1 (EC50 = 0.4 µM). Yaddle1 (15 µM) induces calcium influx in primary human CD4+ T cells, which express Piezo1, and does not decrease the viability of isolated human peripheral blood mononuclear cells (PBMCs) when used at a concentration of 20 µM. It also induces activation of protein kinase D (PKD) in primary human aortic endothelial cells in a Piezo1-dependent manner.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Goon, S., Shiu Chen Liu, C., Ghosh Dastidar, U., et al. Exploring the structural attributes of Yoda1 for the development of new-generation Piezo1 agonist Yaddle1 as a vaccine adjuvant targeting optimal T cell activation. J. Med. Chem. 67(10), 8225-8246 (2024).

    2. Lone, M., Singh, P., Sinnett-Smith, J., et al. Activation of the Piezo1 channel stimulates protein kinase D and migration in human aortic endothelial cells. Am. J. Physiol. Cell Physiol. Online ahead of print, (2025).