An adenosine A2A receptor antagonist
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ANR 94

Item No. 43476

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-ethoxy-9-ethyl-9H-purin-6-amine
CAS Number
634924-89-3
Synonyms
  • 8-ethoxy-9-Ethyladenine
Molecular Formula
C9H13N5O
Formula Weight
207.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
CCOC1=NC2=C(N)N=CN=C2N1CC
InChi Code
InChI=1S/C9H13N5O/c1-3-14-8-6(7(10)11-5-12-8)13-9(14)15-4-2/h5H,3-4H2,1-2H3,(H2,10,11,12)
InChi Key
QUGDTMONBLMLLD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $86

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    10 mg

    $163

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    25 mg

    $387

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    50 mg

    $687

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    Product Description

    ANR 94 is an adenosine A2A receptor antagonist (Ki = 0.046 µM).1 It is selective for the adenosine A2A receptor over adenosine A1, -A2B, and -A3 receptors (Kis = 2.4, >30, and 21 µM, respectively). ANR 94 (5 mg/kg) reduces the number of parkinsonian-like tremors induced by tacrine (Item No. 70240) in rats.2 It decreases neurodegeneration and neuroinflammation in the substantia nigra pars compacta in a mouse model of MPTP-induced Parkinson’s disease when administered at a dose of 0.5 mg/kg. ANR 94 (5 mg/kg) increases alcohol intake but not water or food intake in alcohol-preferring rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Klotz, K.-N., Kachler, S., Lambertucci, C., et al. 9-Ethyladenine derivatives as adenosine receptor antagonists: 2- and 8-substitution results in distinct selectivities. Naunyn Schmiedebergs Arch Pharmacol. 367(6), 629-634 (2003).

    2. Pinna, A., Tronci, E., Schintu, N., et al. A new ethyladenine antagonist of adenosine A2A receptors: Behavioral and biochemical characterization as an antiparkinsonian drug. Neuropharmacology 58(3), 613-623 (2009).

    3. Micioni Di Bonaventura, M.V., Cifani, C., Lambertucci, C., et al. Effects of A2A adenosine receptor blockade or stimulation on alcohol intake in alcohol-preferring rats. Psychopharmacol. (Berl) 219(4), 945-957 (2011).