A CXCR1 and CXCR2 antagonist
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SCH 563705

Item No. 43479

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-[4-(1-methylethyl)-2-furanyl]propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-benzamide
CAS Number
473728-58-4
Molecular Formula
C23H27N3O5
Formula Weight
425.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
O=C(C1=O)C(N[C@@H](C2=CC(C(C)C)=CO2)CC)=C1NC3=C(O)C(C(N(C)C)=O)=CC=C3
InChi Code
InChI=1S/C23H27N3O5/c1-6-15(17-10-13(11-31-17)12(2)3)24-18-19(22(29)21(18)28)25-16-9-7-8-14(20(16)27)23(30)26(4)5/h7-12,15,24-25,27H,6H2,1-5H3/t15-/m1/s1
InChi Key
DGKQQEVYYPCMNE-OAHLLOKOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $120

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    5 mg

    $570

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    10 mg

    $1,020

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    25 mg

    $1,799

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    Product Description

    SCH 563705 is an antagonist of chemokine (C-X-C motif) receptor 1 (CXCR1) and CXCR2 (Kis = 7.3 and 1.3 nM, respectively).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Winkel, A.F., Engel, C.K., Margerie, D., et al. Characterization of RA839, a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling. The Journal of Biological Chemisty 290(47), 27446-28455 (2015).