An internal standard for the quantification of LY2835219
Related Products
Unlabeled Version(s)
21560LY2835219 17740LY2835219 (methanesulfonate)
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LY2835219-d5

Item No. 43483

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[5-[[4-(ethyl-1,1,2,2,2-d5)-1-piperazinyl]methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinamine
CAS Number
1809251-51-1
Molecular Formula
C27H27D5F2N8
Formula Weight
511.6
Purity
≥99% deuterated forms (d1-d5)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
FC(C(C1=CC(F)=C(N=C(C)N2C(C)C)C2=C1)=N3)=CN=C3NC(N=C4)=CC=C4CN5CCN(C([2H])([2H])C([2H])([2H])[2H])CC5
InChi Code
InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34)/i1D3,5D2
InChi Key
UZWDCWONPYILKI-RPIBLTHZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $578

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    Product Description

    LY2835219-d5 is intended for use as an internal standard for the quantification of LY2835219 (Item Nos. 21560 | 17740) by GC- or LC-MS. LY2835219 is an orally bioavailable dual inhibitor of cyclin-dependent kinase 4 (Cdk4) and Cdk6 (IC50s = 2 and 10 nM, respectively).1 Through this mechanism, it blocks phosphorylation of retinoblastoma protein (Rb), resulting in arrest of cell cycling in the G1 phase. LY2835219 has antitumor action against xenografts when used alone or in combination with other chemotherapeutic compounds.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gelbert, L.M., Cai, S., Lin, X., et al. Preclinical characterization of the CDK4/6 inhibitor LY2835219: In-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine. Invest. New. Drugs 32(5), 825-837 (2014).

    2. Tate, S.C., Cai, S., Ajamie, R.T., et al. Semi-mechanistic pharmacokinetic/pharmacodynamic modeling of the antitumor activity of LY2835219, a new cyclin-dependent kinase 4/6 inhibitor, in mice bearing human tumor xenografts. Clin. Cancer Res. 20(14), 3763-3774 (2014).