An IRE1α inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

AMG 18 (hydrochloride)

Item No. 43488

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]-benzenesulfonamide, hydrochloride
Synonyms
  • Kinase-inhibiting RNase Attenuator 8
  • KIRA8
Molecular Formula
C31H29ClN6O3S • XHCl
Formula Weight
601.1
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
CC(C=C1)=C(OC2=C(C3=NC(N[C@@H]4CNCCC4)=NC=C3)C=CC=N2)C5=C1C(NS(C6=C(Cl)C=CC=C6)(=O)=O)=CC=C5.Cl
InChi Code
InChI=1S/C31H29ClN6O3S.ClH/c1-20-13-14-22-23(8-4-11-27(22)38-42(39,40)28-12-3-2-10-25(28)32)29(20)41-30-24(9-6-17-34-30)26-15-18-35-31(37-26)36-21-7-5-16-33-19-21;/h2-4,6,8-15,17-18,21,33,38H,5,7,16,19H2,1H3,(H,35,36,37);1H/t21-;/m0./s1
InChi Key
CNWIPRHGMZTPSB-BOXHHOBZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $76

    Add

    5 mg

    $285

    Add

    10 mg

    $418

    Add

    25 mg

    $950

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    AMG 18 is an inhibitor of inositol-requiring enzyme 1α (IRE1α; IC50 = 0.013 µM).1 It is selective for IRE1α over JNK3 (IC50 = 2.5 µM) and a panel of 100 kinases at 1 µM. AMG 18 inhibits the splicing of X-box binding protein 1 (XBP1) induced by thapsigargin (Item No. 10522) in a reporter assay using HT-1080 cells. It sensitizes 9591PPT and 53631PPT mouse pancreatic ductal adenocarcinoma (PDAC) cells to radiation when used at concentrations of 2.5 or 5 µM.2 AMG 18 (10 µM) reverses increases in fibronectin levels in primary human small airway epithelial cells infected with respiratory syncytial virus (RSV).3 In vivo, AMG 18 (50 mg/kg) decreases blood glucose levels, liver triglyceride and cholesterol levels, and plasma alanine transaminase (ALT) and aspartate aminotransferase (AST) levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine- and choline-deficient (MCD) diet.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Harrington, P.E., Biswas, K., Malwitz, D., et al. Unfolded protein response in cancer: IRE1α inhibition by selective kinase ligands does not impair tumor cell viability. ACS Med. Chem. Lett. 6(1), 68-72 (2014).

    2. Kern, J., Schilling, D., Schneeweis, C., et al. Identification of the unfolded protein response pathway as target for radiosensitization in pancreatic cancer. Radiother. Oncol. 191:110059, (2024).

    3. Zhao, Y., Qiao, D., Skibba, M., et al. The IRE1α-XBP1s arm of the unfolded protein response activates N-glycosylation to remodel the subepithelial basement membrane in paramyxovirus infection. Int. J. Mol. Sci. 23(16), 9000 (2022).

    4. Zhao, S., Liu, X., Li, L., et al. KIRA8 attenuates non-alcoholic steatohepatitis through inhibition of the IRE1α/XBP1 signalling pathway. Biochem. Biophys. Res. Commun. 632, 158-164 (2022).