A cyanotoxin and Nrf2 activator
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[D-Asp3]-Microcystin-LR

Item No. 43503

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl]
CAS Number
120011-66-7
Synonyms
  • [D-Asp3]-Cyanoginosin-LR
  • [D-Asp3]-MC-LR
Molecular Formula
C48H72N10O12
Formula Weight
981.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: 1 mg/ml
SMILES
O=C(CC[C@@H](NC([C@@H](C)[C@H](/C=C/C(C)=C/[C@H](C)[C@H](CC1=CC=CC=C1)OC)N2)=O)C(O)=O)N(C)C(C(N[C@@H](C(N[C@@H](CC(C)C)C(N[C@H](CC(N[C@H](C2=O)CCCNC(N)=N)=O)C(O)=O)=O)=O)C)=O)=C
InChi Code
InChI=1S/C48H72N10O12/c1-26(2)22-36-45(65)57-37(47(68)69)25-39(59)53-34(16-13-21-51-48(49)50)44(64)54-33(18-17-27(3)23-28(4)38(70-9)24-32-14-11-10-12-15-32)29(5)41(61)55-35(46(66)67)19-20-40(60)58(8)31(7)43(63)52-30(6)42(62)56-36/h10-12,14-15,17-18,23,26,28-30,33-38H,7,13,16,19-22,24-25H2,1-6,8-9H3,(H,52,63)(H,53,59)(H,54,64)(H,55,61)(H,56,62)(H,57,65)(H,66,67)(H,68,69)(H4,49,50,51)/b18-17+,27-23+/t28-,29-,30+,33-,34-,35+,36-,37+,38-/m0/s1
InChi Key
VYEBKSHVYPDMQQ-MREVJOSWSA-N
Origin
Bacterium/Microcystis aeruginosa
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    30 µg

    $329

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    Product Description

    [D-Asp3]-Microcystin-LR is a cyanotoxin that has been found in Anabaena and an activator of nuclear factor erythroid 2-related factor 2 (Nrf2).1 It induces Nrf2 activation in HepG2 cells when used at concentrations ranging from 0.3-3 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lundqvist, J., Pekar, H., and Oskarsson, A. Microcystins activate nuclear factor erythroid 2-related factor 2 (Nrf2) in human liver cells in vitro - Implications for an oxidative stress induction by microcystins. Toxicon 126, 47-50 (2017).