A phytosterol with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Friedelin

Item No. 43506

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4β,5β,8α,9β,10α,13α,14β)-5,9,13-trimethyl-24,25,26-trinoroleanan-3-one
CAS Number
559-74-0
Synonyms
  • Friedelanone
  • (–)-Friedelin
  • NSC 55141
Molecular Formula
C30H50O
Formula Weight
426.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly soluble: 0.1-1 mg/ml
SMILES
C[C@@]12[C@]([C@@]3([H])[C@@](CC1)(CCC(C)(C3)C)C)(CC[C@@]4([C@]2([H])CC[C@]5([C@@]4([H])CCC([C@@H]5C)=O)C)C)C
InChi Code
InChI=1S/C30H50O/c1-20-21(31)9-10-22-27(20,5)12-11-23-28(22,6)16-18-30(8)24-19-25(2,3)13-14-26(24,4)15-17-29(23,30)7/h20,22-24H,9-19H2,1-8H3/t20-,22+,23-,24+,26+,27+,28-,29+,30-/m0/s1
InChi Key
OFMXGFHWLZPCFL-SVRPQWSVSA-N
Origin
Plant/(Imperata cylindrica (L.) P. Beauv.)
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $36

    Add

    5 mg

    $168

    Add

    10 mg

    $264

    Add

    25 mg

    $616

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Friedelin is a phytosterol that has been found in L. eriocalyx and has diverse biological activities.1,2 It scavenges DPPH (Item No. 14805) radicals in a cell-free assay (IC50 = 21.1 mM).1 Friedelin is toxic to mosquito larvae and adults (LC50s = 456.99 and 891.23 µg/ml, respectively).2 It decreases the proliferation of P. falciparum (IC50 = 250.7 ng/ml). In vivo, friedelin (40 mg/kg per day) reduces serum levels of glutamate dehydrogenase (GDH), alanine transaminase (ALT), and lactate dehydrogenase (Ldh) and increases hepatic levels of superoxide dismutase (SOD), catalase (Cat), glutathione (GSH), and glutathione peroxidase (Gpx) in a rat model of liver damage induced by carbon tetrachloride (CCl4).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sunil, C., Duraipandiyan, V., Ignacimuthu, S., et al. Antioxidant, free radical scavenging and liver protective effects of friedelin isolated from Azima tetracantha Lam. leaves. Food Chem. 139(1-4), 860-865 (2013).

    2. Manguro, L.O.A., Owuor, P.O., and Ochung, A.A. Isolation, characterization and biological activities of phytoconstituents from Lonchocarpus eriocalyx harms leaves. Trends Phytochem. Res. 2(3), 135-146 (2018).