A dual σ receptor antagonist and dopamine transporter inhibitor
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CM699 (hydrochloride)

Item No. 43519

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3-dihydro-1-methyl-3-[4-(spiro[isobenzofuran-1(3H),4′-piperidin]-1′-yl)butyl]-2H-benzimidazol-2-one, monohydrochloride
Molecular Formula
C24H29N3O2 • HCl
Formula Weight
428.0
Purity
≥98%
Formulation
A neat solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Soluble: ≥ 10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
CN1C2=C(C=CC=C2)N(C1=O)CCCCN3CCC4(CC3)C5=C(CO4)C=CC=C5.Cl
InChi Code
InChI=1S/C24H29N3O2.ClH/c1-25-21-10-4-5-11-22(21)27(23(25)28)15-7-6-14-26-16-12-24(13-17-26)20-9-3-2-8-19(20)18-29-24;/h2-5,8-11H,6-7,12-18H2,1H3;1H
InChi Key
IQIQXQIYPCEHPA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $64

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    5 mg

    $128

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    10 mg

    $224

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    Product Description

    CM699 is a dual σ receptor antagonist (Kis = 0.0141 and 0.00231 µM for the σ1 and σ2 receptors, respectively) and dopamine transporter (DAT) inhibitor (Ki = 0.311 µM).1 It is selective for the σ1 and σ2 receptors and DAT over the serotonin transporter (SERT; Ki = 2.83 µM) but also binds to the norepinephrine transporter (NET; Ki = 0.232 µM). CM699 inhibits dopamine uptake in rat striatal synaptosomes (IC50 = 6.01 µM) and induces σ1 receptor multimerization, indicating antagonist activity, in HEK293 cells expressing the human receptor when used at a concentration of 20 µM. In vivo, CM699 decreases self-administration of cocaine in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hiranita, T., Hong, W.C., Sharma, A., et al. Preclinical profile of CM699 as a medication candidate for stimulant use disorder. ACS Chem. Neurosci. 16(8), 1454-1468 (2025).