An imidazoline I1 receptor antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

BRD4780 (hydrochloride)

Item No. 43542

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,2R,3R,4S)-rel-3-(1-methylethyl)-bicyclo[2.2.1]heptan-2-amine, monohydrochloride
CAS Number
1021868-90-5
Molecular Formula
C10H19N • HCl
Formula Weight
189.7
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Soluble: ≥ 10 mg/mlPBS (pH 7.2): Soluble: ≥ 10 mg/ml
SMILES
CC([C@H]1[C@@]2([H])C[C@@](CC2)([H])[C@@H]1N)C.Cl
InChi Code
InChI=1S/C10H19N.ClH/c1-6(2)9-7-3-4-8(5-7)10(9)11;/h6-10H,3-5,11H2,1-2H3;1H/t7-,8+,9+,10+;/m1./s1
InChi Key
KSTGYMXUFHCTSM-MRUBQFBLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $31

    Add

    5 mg

    $147

    Add

    10 mg

    $247

    Add

    50 mg

    $1,001

    Add
    Product Description

    BRD4780 is an antagonist of the imidazoline I1 receptor (Ki = 42 nM).1 It is selective for the imidazoline I1 receptor over α1-, α2A-, α2B-, and α2C-adrenergic receptors (Kis = >100, >20, >20, and >20 µM, respectively). BRD4780 also binds to transmembrane P24 trafficking protein 9 (TMED9) in a thermal shift assay and releases mucin 1-fs (MUC1-fs), a mutant form of MUC1 caused by a frameshift mutation in MUC1, from TMED9-containing vesicles in kidney cells isolated from patients with MUC1 kidney disease.2 In vivo, BRD4780 (1, 10, and 50 mg/kg) reduces renal MUC1-fs accumulation in transgenic mice heterozygous for human MUC1-fs.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Munk, S.A., Lai, R.K., Burke, J.E., et al. Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent. J. Med. Chem. 39(6), 1193-1195 (1996).

    2. Dvela-Levitt, M., Kost-Alimova, M., Emani, M., et al. Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy. Cell 178(3), 521-535 (2019).