An iboga alkaloid derivative
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Product Categories

Product Type

Biochemicals

Research Area

Neuroscience
Pain Research

PNU 22394 (hydrochloride)

Item No. 43564

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,3,4,5,6-hexahydro-6-methyl-azepino[4,5-b]indole, monohydrochloride
CAS Number
15923-42-9
Molecular Formula
C13H16N2 • HCl
Formula Weight
236.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
CN1C(CCNCC2)=C2C3=C1C=CC=C3.Cl
InChi Code
InChI=1S/C13H16N2.ClH/c1-15-12-5-3-2-4-10(12)11-6-8-14-9-7-13(11)15;/h2-5,14H,6-9H2,1H3;1H
InChi Key
SAIGGEUWSYESTR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $43

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    5 mg

    $129

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    10 mg

    $215

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    25 mg

    $429

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    Product Description

    PNU 22394 is an iboga alkaloid derivative.1 In vivo, PNU 22394 (30 mg/kg) increases licking latency in a cold plate test and paw withdrawal threshold in a paw pressure test in a mouse model of neuropathic pain induced by oxaliplatin (Item No. 13106).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Arias, H.R., Micheli, L., Jensen, A.A., et al. Ibogalogs decrease neuropathic pain in mice through a mechanism involving crosstalk between 5-HT2A and mGlu2 receptors. Biomed. Pharmacother. 184, 117887 (2025).