A Cdk8 and Cdk19 inhibitor
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BI-1347

Item No. 43667

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[4-(4-isoquinolinyl)phenyl]-N,N-dimethyl-1H-pyrazole-1-acetamide
CAS Number
2163056-91-3
Molecular Formula
C22H20N4O
Formula Weight
356.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(N(C)C)CN1N=CC(C2=CC=C(C3=C4C=CC=CC4=CN=C3)C=C2)=C1
InChi Code
InChI=1S/C22H20N4O/c1-25(2)22(27)15-26-14-19(12-24-26)16-7-9-17(10-8-16)21-13-23-11-18-5-3-4-6-20(18)21/h3-14H,15H2,1-2H3
InChi Key
WULUGQONDYDNKY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $82

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    10 mg

    $156

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    25 mg

    $367

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    100 mg

    $814

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    Product Description

    BI-1347 is an inhibitor of Cdk8 and Cdk19 (IC50s = 1.4 and 1.7 nM, respectively).1 It is selective for Cdk8 and Cdk19 over Cdk1, -2, -4, -6, -7, and -9 and a panel of 318 additional kinases at 1 µM. In vivo, BI-1347 (10 mg/kg) reduces tumor volume in an MV4-11 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hofmann, M.H., Mani, R., Engelhardt, H., et al. Selective and potent CDK8/19 inhibitors enhance NK-cell activity and promote tumor surveillance. Mol. Cancer Ther. 19(4), 1018-1030 (2020).