A Cdk12 and Cdk13 inhibitor
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Cdk12-IN-2

Item No. 43703

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[trans-4-[(5-cyano-2-pyridinyl)amino]cyclohexyl]-N-[4-(1,6- dihydro-1-methyl-6-oxo-3-pyridinyl)phenyl]-N′-(phenylmethyl)-urea
CAS Number
2244987-03-7
Synonyms
  • Cdk12 Inhibitor 2
  • Cyclin-dependent Kinase 12-IN-2
  • Cyclin-dependent Kinase 12 Inhibitor 2
Molecular Formula
C32H32N6O2
Formula Weight
532.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(NCC1=CC=CC=C1)N([C@@H]2CC[C@H](CC2)NC3=CC=C(C#N)C=N3)C(C=C4)=CC=C4C(C=C5)=CN(C)C5=O
InChi Code
InChI=1S/C32H32N6O2/c1-37-22-26(10-18-31(37)39)25-8-13-28(14-9-25)38(32(40)35-20-23-5-3-2-4-6-23)29-15-11-27(12-16-29)36-30-17-7-24(19-33)21-34-30/h2-10,13-14,17-18,21-22,27,29H,11-12,15-16,20H2,1H3,(H,34,36)(H,35,40)/t27-,29-
InChi Key
HDJBGURZVALLMD-KWQFAZJVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $65

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    5 mg

    $260

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    10 mg

    $423

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    25 mg

    $812

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    Product Description

    Cdk12-IN-2 is an inhibitor of Cdk12 and Cdk13 (IC50s = 0.052 and 0.01 µM, respectively).1 It is selective for Cdk12 over Cdk2, -7, -8, and -9 (IC50s = >100, >10, >10, and 16 µM, respectively). Cdk12-IN-2 inhibits RNA polymerase II phosphorylation in SK-BR-3 cells (IC50 = 0.195 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ito, M., Tanaka, T., Toita, A., et al. Discovery of 3-benzyl-1-( trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea derivatives as novel and selective cyclin-dependent kinase 12 (CDK12) inhibitors. J. Med. Chem. 61(17), 7710-7728 (2018).