An NR5A1 inhibitor
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Small Molecule Modulators
Receptor Pharmacology
Antagonists

Research Area

Cancer

SID 7969543

Item No. 43705

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[2-[2-[(2,3-dihydro-1,4-benzodioxin-6-yl)amino]2-oxoethyl]-1,2-dihydro-1-oxo-5-isoquinolinyl]oxy]-propanoic acid, ethyl ester
CAS Number
868224-64-0
Molecular Formula
C24H24N2O7
Formula Weight
452.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(NC1=CC=C2OCCOC2=C1)CN3C=CC4=C(C=CC=C4OC(C(OCC)=O)C)C3=O
InChi Code
InChI=1S/C24H24N2O7/c1-3-30-24(29)15(2)33-19-6-4-5-18-17(19)9-10-26(23(18)28)14-22(27)25-16-7-8-20-21(13-16)32-12-11-31-20/h4-10,13,15H,3,11-12,14H2,1-2H3,(H,25,27)
InChi Key
KWMBIIQCLUIHDI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $64

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    10 mg

    $115

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    25 mg

    $272

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    50 mg

    $511

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    Cayman Chemical
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    Product Description

    SID 7969543 is an inhibitor of nuclear receptor subfamily 5 group A member 1 (NR5A1), also known as steroidogenic factor 1 (SF-1; IC50 = 760 nM).1 It is selective for NR5A1/SF-1 over retinoic acid receptor-related orphan receptor α (RORα) and the herpes simplex virus (HSV) transcriptional activator VP16 (IC50s = >33.333 µM for both). SID 7969543 is selectively cytotoxic to PER-485, THP-1, and MOLM-13 leukemia cells, which contain mixed-lineage leukemia 1 (MLL1) rearrangement mutations (IC50s = 1.4, 2.6, and 1 µM, respectively), over a panel of wild-type MLL1-containing leukemia cells and MRC-5 fibroblasts (IC50s = >20 µM for all).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Madoux, F., Li, X., Chase, P., et al. Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol. Pharmacol. 73(6), 1776-1784 (2008).

    2. Karsa, M., Ronca, E., Bongers, A., et al. Systematic in vitro evaluation of a library of approved and pharmacologically active compounds for the identification of novel candidate drugs for KMT2A-rearranged leukemia. Front. Oncol. 11, 779859 (2022).