A SIRT5 inhibitor
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MC3482 (trifluoroacetate salt)

Item No. 43725

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S,12S)-12-carboxy-9,14-dioxo-16-phenyl-3-[(phenylamino)carbonyl]-15-oxa-2,8,13-triazahexadecanoic acid, 1-(phenylmethyl) ester, trifluoroacetate salt
Molecular Formula
C33H38N4O8 • XCF3COOH
Formula Weight
618.7
Purity
≥85%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(NCCCC[C@@H](C(NC1=CC=CC=C1)=O)NC(OCC2=CC=CC=C2)=O)CC[C@H](NC(OCC3=CC=CC=C3)=O)C(O)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C33H38N4O8.C2HF3O2/c38-29(20-19-28(31(40)41)37-33(43)45-23-25-14-6-2-7-15-25)34-21-11-10-18-27(30(39)35-26-16-8-3-9-17-26)36-32(42)44-22-24-12-4-1-5-13-24;3-2(4,5)1(6)7/h1-9,12-17,27-28H,10-11,18-23H2,(H,34,38)(H,35,39)(H,36,42)(H,37,43)(H,40,41);(H,6,7)/t27-,28-;/m0./s1
InChi Key
AKGNNEKWORAHPU-DHBRAOIWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $89

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    10 mg

    $142

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    25 mg

    $312

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    50 mg

    $534

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    MC3482 is an inhibitor of sirtuin 5 (SIRT5).1 It is selective for SIRT5 over SIRT1 and SIRT3 at 50 µM. MC3482 (50 µM) induces autophagy and mitophagy in MDA-MB-231 cells and decreases lipid droplet size and increases lipolysis and the oxygen consumption rate (OCR) in differentiated 3T3-L1 adipocytes.1,2 In vivo, MC3482 (2 mg/kg) decreases brain water content, infarct volume, and neurological deficits in a mouse model of cerebral ischemia induced by middle cerebral artery occlusion (MCAO).3 It decreases airway hyperresponsiveness, serum IgE levels, neutrophil and eosinophil bronchoalveolar lavage fluid (BALF) infiltration, epithelial hyperplasia, and mucus production in a mouse model of toluene-2,4-diisocyanate-induced asthma.4 MC3482 increases the paw withdrawal threshold in a mouse model of complete Freund’s adjuvant-induced inflammatory pain.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Polletta, L., Vernucci, E., Carnevale, I., et al. SIRT5 regulation of ammonia-induced autophagy and mitophagy. Autophagy 11(2), 253-270 (2015).

    2. Molinari, F., Feraco, A., Mirabilii, S., et al. SIRT5 inhibition induces brown fat-like phenotype in 3T3-L1 preadipocytes. Cells 10(5), 1126 (2021).

    3. Xia, Q., Yu, Y., Zhan, G., et al. The sirtuin 5 inhibitor MC3482 ameliorates microglia‑induced neuroinflammation following ischaemic stroke by upregulating the succinylation level of annexin-A1. J. Neuroimmune Pharmacol. 19(1), 17 (2024).

    4. Wu, J., Wang, Y., Zhang, Q., et al. SIRT5 regulates fatty acid oxidation and mitochondrial oxidative stress to exacerbate airway inflammation in experimental asthma. Cell. Signal. 136, 112149 (2025).

    5. Zuo, C.-Y., Gou, C.-Y., Zhang, C.-S., et al. Role of SIRT5 in the analgesic effectiveness of moxibustion at ST36 in mice with inflammatory pain. Heliyon 9(7), e17765 (2023).