A p300 inhibitor
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CCT077791

Item No. 43794

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-chloro-2-(4-nitrophenyl)-3(2H)-isothiazolone
CAS Number
748777-47-1
Molecular Formula
C9H5ClN2O3S
Formula Weight
256.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C1C=C(SN1C2=CC=C([N+]([O-])=O)C=C2)Cl
InChi Code
InChI=1S/C9H5ClN2O3S/c10-8-5-9(13)11(16-8)6-1-3-7(4-2-6)12(14)15/h1-5H
InChi Key
RBOAUBASDMUWJM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $83

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    5 mg

    $248

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    10 mg

    $455

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    Cayman Chemical
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    Product Description

    CCT077791 is an inhibitor of the histone acetyltransferase p300 (IC50 = 7.3 µM).1 It is also active against S. aureus, S. epidermidis, and B. subtilis (MICs = 2.5, 0.3, and 2.5 µg/ml, respectively).2 CCT077791 (10 µM) decreases global protein, histone H3 and H4, and α-tubulin acetylation in HCT116 colorectal cancer cells.1 It inhibits growth of HCT116 cells and HT-29 colon cancer cells (GI50s = 3 and 2.1 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stimson, L., Rowlands, M.G., Newbatt, Y.M., et al. Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity. Mol. Cancer Ther. 4(10), 1521-1532 (2005).

    2. Khalaj, A., Adibpour, N., Shahverdi, A.R., et al. Synthesis and antibacterial activity of 2-(4-substituted phenyl)-3(2H)-isothiazolones. Eur. J. Med. Chem. 39(8), 699-705 (2004).