An internal standard for the quantification of robenidine
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Unlabeled Version(s)
43792Robenidine (hydrochloride)
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Robenidine-d8 (hydrochloride)

Item No. 43810

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2′-bis[(4-chlorophenyl-2,3,5,6-d4)-methylene]-carbonimidic dihydrazide, monohydrochloride
CAS Number
1173097-77-2
Molecular Formula
C15H5Cl2D8N5 • HCl
Formula Weight
378.7
Purity
≥99% deuterated forms (d1-d8)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
ClC(C([2H])=C1[2H])=C([2H])C([2H])=C1C=NNC(NN=CC2=C([2H])C([2H])=C(C([2H])=C2[2H])Cl)=N.Cl
InChi Code
InChI=1S/C15H13Cl2N5.ClH/c16-13-5-1-11(2-6-13)9-19-21-15(18)22-20-10-12-3-7-14(17)8-4-12;/h1-10H,(H3,18,21,22);1H/i1D,2D,3D,4D,5D,6D,7D,8D;
InChi Key
LTWIBTYLSRDGHP-AGHVBCBTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Robenidine-d8 is intended for use as an internal standard for the quantification of robenidine (Item no. 43792) by GC- or LC-MS. Robenidine is an anticoccidial agent.1 It is also active against methicillin-resistant S. aureus (MRSA) and vancomycin-resistant enterococci (VRE; MICs = 6.1 and 7.4 µM, respectively).2 Dietary administration of robendine reduces weight gain, decreases intestinal lesion and oocyst numbers, and increases survival in E. acervuline-, E. brunetti-, E. mivati-, E. necatrix-, or E. tenella-infected chickens. Formulations containing robenidine have been used in animal feed for the prevention of coccidiosis or control of necrotic enteritis in chickens.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kennett, R.L., Kantor, S., and Gallo, A. Efficacy studies with robenidine, a new type of anticoccidial, in the diet. Poult. Sci. 53(3), 978-986 (1974).

    2. Abraham, R.J., Stevens, A.J., Young, K.A., et al. Robenidine analogues as gram-positive antibacterial agents. J. Med. Chem. 59(5), 2126-2138 (2016).