A p300 inhibitor
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DS9300

Item No. 43812

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,4R)-1-[[4,4-difluoro-1-(4-methoxyphenyl)cyclohexyl]carbonyl]-4-fluoro-N-1H-pyrazolo[4,3-b]pyridin-5-yl-2-pyrrolidinecarboxamide
CAS Number
2259641-46-6
Molecular Formula
C25H26F3N5O3
Formula Weight
501.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
F[C@H]1CN(C(C2(CCC(F)(CC2)F)C3=CC=C(OC)C=C3)=O)[C@@H](C(NC4=CC=C5NN=CC5=N4)=O)C1
InChi Code
InChI=1S/C25H26F3N5O3/c1-36-17-4-2-15(3-5-17)24(8-10-25(27,28)11-9-24)23(35)33-14-16(26)12-20(33)22(34)31-21-7-6-18-19(30-21)13-29-32-18/h2-7,13,16,20H,8-12,14H2,1H3,(H,29,32)(H,30,31,34)/t16-,20-/m1/s1
InChi Key
UCKDTCZSOLMOMQ-OXQOHEQNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $329

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    10 mg

    $526

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    25 mg

    $1,070

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    50 mg

    $1,810

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    Cayman Chemical
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    Product Description

    DS9300 is an inhibitor of histone acetyltransferase p300 (IC50 = 28 nM).1 It inhibits acetylation of lysine 27 on histone H3 (H3K27) in LK-2 cells (IC50 = 54 nM). DS9300 inhibits the growth of VCaP prostate cancer cells (GI50 = 0.6 nM). In vivo, DS9300 (0.3-3 mg/kg) reduces tumor volume in a VCaP castrated mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kanada, R., Kagoshima, Y., Suzuki, T., et al. Discovery of DS-9300: A highly potent, selective, and once-daily oral EP300/CBP histone acetyltransferase inhibitor. J. Med. Chem. 66(1), 695-715 (2023).