A PFKFB3 inhibitor
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AZ-PFKFB3-67

Item No. 43952

Product Insert (PDF)
Technical Information
Formal Name
N-[4-[[3-cyano-1-[(3,5-dimethyl-4-isoxazolyl)methyl]-1H-indol-5-yl]oxy]phenyl]-2S-pyrrolidinecarboxamide
CAS Number
1704741-11-6
Molecular Formula
C26H25N5O3
Formula Weight
455.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Soluble: ≥ 10 mg/mlDMSO: Sparingly Soluble: 1-10mg/ml
SMILES
O=C(NC1=CC=C(OC2=CC=C3N(CC4=C(ON=C4C)C)C=C(C#N)C3=C2)C=C1)[C@@H]5CCCN5
InChi Code
InChI=1S/C26H25N5O3/c1-16-23(17(2)34-30-16)15-31-14-18(13-27)22-12-21(9-10-25(22)31)33-20-7-5-19(6-8-20)29-26(32)24-4-3-11-28-24/h5-10,12,14,24,28H,3-4,11,15H2,1-2H3,(H,29,32)/t24-/m0/s1
InChi Key
NDIKFKQBWGMLCA-DEOSSOPVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

    $154

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    10 mg

    $213

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    25 mg

    $482

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    Product Description

    AZ-PFKFB3-67 is an inhibitor of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase 3 (PFKFB3; IC50 = 0.011 µM).1 It is selective for PFKFB3 over PFKFB1 and PFKFB2 (IC50s = 1.13 and 0.159 µM). It inhibits the formation of fructose-1,6-bisphosphate in A549 cells (IC50 = 0.281 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boyd, S., Brookfield, J.L., Critchlow, S.E., et al. Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3. J. Med. Chem. 58(8), 3611-3625 (2015).