An inducer of neuronal differentiation
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Neuropathiazol

Item No. 43953

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[methyl(2-phenyl-4-thiazolyl)amino]-benzoic acid, ethyl ester
CAS Number
880090-88-0
Molecular Formula
C19H18N2O2S
Formula Weight
338.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C1=CC=C(N(C)C2=CSC(C3=CC=CC=C3)=N2)C=C1)OCC
InChi Code
InChI=1S/C19H18N2O2S/c1-3-23-19(22)15-9-11-16(12-10-15)21(2)17-13-24-18(20-17)14-7-5-4-6-8-14/h4-13H,3H2,1-2H3
InChi Key
MGKYEWWFHSESJN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $87

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    10 mg

    $165

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    25 mg

    $348

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    50 mg

    $479

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    Product Description

    Neuropathiazol is an inducer of neuronal differentiation.1 It induces differentiation of primary rat hippocampal neural progenitor cells when used at a concentration of 10 µM. Neuropathiazol (20 mg/kg per day), alone and in combination with cyclophosphamide (Item No. 13849), decreases tumor volume in an SK-N-AS neuroblastoma mouse xenograft model.2 It increases intratumoral levels of neuronatin, microtubule-associated protein 2 (MAP2), and neurofilament light polypeptide (NF-L), markers of differentiation, in the same model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Warashina, M., Min, K.H., Kuwabara, T., et al. A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells. Angew. Chem. Int. Ed. Engl. 45(4), 591-593 (2006).

    2. Xu, H., Zhang, F., Xu, Y., et al. Neuropathiazol induces neuronal-like differentiation in neuroblastoma cells via upregulation of PEG5. Pediatr. Res. (2025).