A KAT6A and KAT6B inhibitor
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PF-07248144

Item No. 43955

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-methoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]-benzenesulfonamide
CAS Number
2569008-99-5
Molecular Formula
C19H18N4O5S
Formula Weight
414.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=S(NC1=NOC2=CC(CN3C=CC=N3)=CC(OC)=C12)(C4=CC=CC=C4OC)=O
InChi Code
InChI=1S/C19H18N4O5S/c1-26-14-6-3-4-7-17(14)29(24,25)22-19-18-15(27-2)10-13(11-16(18)28-21-19)12-23-9-5-8-20-23/h3-11H,12H2,1-2H3,(H,21,22)
InChi Key
RCBWSTJGOASLEO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $72

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    5 mg

    $323

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    10 mg

    $501

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    25 mg

    $984

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    Product Description

    PF-07248144 is an inhibitor of lysine acetyltransferase 6A (KAT6A), also known as monocytic leukemia zinc finger protein (MOZ) and KAT6B, also known as monocytic leukemia zinc finger protein-related factor (MORF).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mukohara, T., Park, Y.H., Sommerhalder, D., et al. Inhibition of lysine acetyltransferase KAT6 in ER+HER2- metastatic breast cancer: A phase 1 trial. Nat. Med. 30(8), 2242-2250 (2024).