A CK2 inhibitor
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GO289

Item No. 43959

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-bromo-2-methoxy-4-[[[3-(methylthio)-5-phenyl-4H-1,2,4-triazol-4-yl]imino]methyl]-phenol
CAS Number
694522-87-7
Molecular Formula
C17H15BrN4O2S
Formula Weight
419.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
CSC1=NN=C(C2=CC=CC=C2)N1N=CC3=C(Br)C=C(O)C(OC)=C3
InChi Code
InChI=1S/C17H15BrN4O2S/c1-24-15-8-12(13(18)9-14(15)23)10-19-22-16(20-21-17(22)25-2)11-6-4-3-5-7-11/h3-10,23H,1-2H3
InChi Key
DARDDBZKGVEVKB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $104

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    10 mg

    $193

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    25 mg

    $379

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    Product Description

    GO289 is an inhibitor of casein kinase 2 (CK2; IC50 = 7 nM).1 It is selective for CK2 over a panel of 59 other kinases at 5 µM. GO289 (8 or 24 µM) increases the circadian period in a reporter assay using U2OS cells. It decreases levels of phosphorylated Akt and cell division cycle 37 (Cdc37) in C2C12 skeletal muscle myoblasts when used at concentrations of 1, 2, 3, or 4 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Oshima, T., Niwa, Y., Kuwata, K., et al. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Sci. Adv. 5(1), eaau9060 (2019).

    2. Borgo, C., Cesaro, L., Hirota, T., et al. Comparing the efficacy and selectivity of Ck2 inhibitors. A phosphoproteomics approach. Eur. J. Med. Chem. 214, 113217 (2021).