An internal standard for the quantification of 2-hydroxybutyrate
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2-Hydroxybutyrate-d3 (sodium salt)

Item No. 44009

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-butanoic-2,3,3-d3 acid, monosodium salt
CAS Number
1219798-97-6
Synonyms
  • 2-HB-d3
  • α-Hydroxybutyrate-d3
  • DL-2-Hydroxybutyric Acid-d3
Molecular Formula
C4H4D3O3 • Na
Formula Weight
129.1
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleWater: Soluble
SMILES
[O-]C(C(O)([2H])C([2H])([2H])C)=O.[Na+]
InChi Code
InChI=1S/C4H8O3.Na/c1-2-3(5)4(6)7;/h3,5H,2H2,1H3,(H,6,7);/q;+1/p-1/i2D2,3D;
InChi Key
MOSCXNXKSOHVSQ-LCZHFHQESA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $87

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    5 mg

    $392

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    10 mg

    $653

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    2-Hydroxybutyrate-d3 is intended for use as an internal standard for the quantification of 2-hydroxybutyrate by GC- or LC-MS. 2-Hydroxybutyrate is an endogenous metabolite.1 It is formed from 2-oxobutyrate by lactate dehydrogenase (LDH) as a byproduct of cysteine biosynthesis. 2-Hydroxybutyrate (500 µM) inhibits branched-chain amino acid transaminase 2 (BCAT2) in a cell-free assay and increases the NAD+/NADH ratio in C2C12 myoblasts. It increases soleus muscle resistance to fatigue in mice when administered at a dose of 1 mmol/kg. Plasma levels of 2-hydroxybutyrate increase with increasing insulin resistance and dysglycemia in nondiabetic patients.2 Increased serum levels of 2-hydroxybutyrate are associated with increased 3-month mortality in patients with acute heart failure.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wadsworth, B.J., Leiwe, M., Minogue, E.A., et al. A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue. Elife 12:RP92707, (2024).

    2. Gall, W.E., Beebe, K., Lawton, K.A., et al. α-Hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population. PLoS One 5(5), e10883 (2010).

    3. Stryeck, S., Gastrager, M., Degoricija, V., et al. Serum concentrations of citrate, tyrosine, 2- and 3-hydroxybutyrate are associated with increased 3-month mortality in acute heart failure patients. Sci. Rep. 9(1), 6743 (2019).