An antibacterial peptide
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IDR 1018 (acetate)

Item No. 44012

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-valyl-L-arginyl-L-leucyl-L-isoleucyl-L-valyl-L-alanyl-L-valyl-L-arginyl-L-isoleucyl-L-tryptophyl-L-arginyl-L-argininamide, acetate
Molecular Formula
C71H126N26O12 • XC2H4O2
Formula Weight
1536.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
VRLIVAVRIWRR-NH2
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlWater: Slightly soluble: 0.1-1 mg/ml
SMILES
CC[C@@H]([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC1=CNC2=C1C=CC=C2)=O)NC([C@@H](NC([C@H](C(C)C)NC([C@@H](NC([C@H](C(C)C)NC([C@H]([C@H](CC)C)NC([C@@H](NC([C@@H](NC([C@H](C(C)C)N)=O)CCCNC(N)=N)=O)CC(C)C)=O)=O)=O)C)=O)=O)CCCNC(N)=N)=O)C.CC(O)=O
InChi Code
InChI=1S/C71H126N26O12.C2H4O2/c1-14-39(11)54(66(108)93-50(33-42-34-86-44-23-17-16-22-43(42)44)61(103)89-46(25-19-29-83-69(76)77)58(100)88-45(56(73)98)24-18-28-82-68(74)75)96-60(102)48(27-21-31-85-71(80)81)91-65(107)53(38(9)10)94-57(99)41(13)87-64(106)52(37(7)8)95-67(109)55(40(12)15-2)97-62(104)49(32-35(3)4)92-59(101)47(26-20-30-84-70(78)79)90-63(105)51(72)36(5)6;1-2(3)4/h16-17,22-23,34-41,45-55,86H,14-15,18-21,24-33,72H2,1-13H3,(H2,73,98)(H,87,106)(H,88,100)(H,89,103)(H,90,105)(H,91,107)(H,92,101)(H,93,108)(H,94,99)(H,95,109)(H,96,102)(H,97,104)(H4,74,75,82)(H4,76,77,83)(H4,78,79,84)(H4,80,81,85);1H3,(H,3,4)/t39-,40-,41-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-;/m0./s1
InChi Key
LRGVZTXWLGHRPR-XIQVEKCESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    IDR 1018 is an antibacterial peptide.1 It is active against P. aeruginosa and S. aureus (MICs = 19 and 5 µg/ml, respectively). IDR 1018 (20 µg/ml) decreases TNF-α secretion induced by LPS in isolated human peripheral blood mononuclear cells (PBMCs). It reduces biofilm formation by P. aeruginosa, A. baumannii, S. enterica, and methicillin-resistant S. aureus (MRSA) when used in combination with ceftazidime (Item No. 14828).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wieczorek, M., Jenssen, H., Kindrachuk, J., et al. Structural studies of a peptide with immune modulating and direct antimicrobial activity. Chem. Biol. 17(9), 970-980 (2010).

    2. Reffuveille, F., de la Fuente-Núñez, C., Mansour, S., et al. A broad-spectrum antibiofilm peptide enhances antibiotic action against bacterial biofilms. Antimicrob. Agents Chemother. 58(9), 5363-5371 (2014).