An autoantigenic peptide for β-cells
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IGRP (206-214) (mouse) (trifluoroacetate salt)

Item No. 44049

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-valyl-L-tyrosyl-L-leucyl-L-lysyl-L-threonyl-L-asparaginyl-L-valyl-L-phenylalanyl-L-leucine, trifluoroacetate salt
Synonyms
  • Islet-specific Glucose-6-phosphatase Catalytic Subunit-related Protein (206-214)
  • Val-Tyr-Leu-Lys-Thr-Asn-Val-Phe-Leu-OH
Molecular Formula
C54H85N11O13 • XCF3COOH
Formula Weight
1096.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Peptide Sequence
VYLKTNVFL-OH
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlWater: Slightly soluble: 0.1-1 mg/ml
SMILES
OC(C=C1)=CC=C1C[C@H](NC([C@@H](N)C(C)C)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C54H85N11O13.C2HF3O2/c1-28(2)23-37(59-48(71)38(60-51(74)43(57)30(5)6)26-34-18-20-35(67)21-19-34)47(70)58-36(17-13-14-22-55)46(69)65-45(32(9)66)53(76)62-40(27-42(56)68)50(73)64-44(31(7)8)52(75)61-39(25-33-15-11-10-12-16-33)49(72)63-41(54(77)78)24-29(3)4;3-2(4,5)1(6)7/h10-12,15-16,18-21,28-32,36-41,43-45,66-67H,13-14,17,22-27,55,57H2,1-9H3,(H2,56,68)(H,58,70)(H,59,71)(H,60,74)(H,61,75)(H,62,76)(H,63,72)(H,64,73)(H,65,69)(H,77,78);(H,6,7)/t32-,36+,37+,38+,39+,40+,41+,43+,44+,45+;/m1./s1
InChi Key
VROCKRPDSNYZLO-FJPQRQDCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) (206-214) is an autoantigenic peptide for β-cells.1 It promotes mouse T cell-induced lysis of RMA-S cells expressing the MHC class I receptor in a concentration-dependent manner. IGRP (206-214) is bound in a tetramer assay by CD8+ T cells isolated from pancreatic islets but not those isolated from peripheral blood in non-obese diabetic mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lieberman, S.M., Evans, A.M., Han, B., et al. Identification of the β cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes. Proc. Natl. Acad. Sci. USA 100(14), 8384-8388 (2003).