An inhibitor of integrin α4β1
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BIO-5192

Item No. 44105

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-2-[[[(2S)-1-[(3,5-dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methyl phenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl] amino]-butanoic acid
CAS Number
327613-57-0
Synonyms
  • AMD 15057
Molecular Formula
C38H46Cl2N6O8S
Formula Weight
817.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
ClC1=CC(S(N2CCC[C@H]2C(N[C@@H](CCNC([C@@H](N(C(CC3=CC=C(NC(NC4=C(C)C=CC=C4)=O)C=C3)=O)C)CC(C)C)=O)C(O)=O)=O)(=O)=O)=CC(Cl)=C1
InChi Code
InChI=1S/C38H46Cl2N6O8S/c1-23(2)18-33(45(4)34(47)19-25-11-13-28(14-12-25)42-38(52)44-30-9-6-5-8-24(30)3)35(48)41-16-15-31(37(50)51)43-36(49)32-10-7-17-46(32)55(53,54)29-21-26(39)20-27(40)22-29/h5-6,8-9,11-14,20-23,31-33H,7,10,15-19H2,1-4H3,(H,41,48)(H,43,49)(H,50,51)(H2,42,44,52)/t31-,32-,33-/m0/s1
InChi Key
MNQBPRHHZPXCKZ-ZDCRTTOTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $46

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    5 mg

    $207

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    10 mg

    $345

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    Product Description

    BIO-5192 is an inhibitor of integrin α4β1, also known as very late antigen-4 (VLA-4; IC50 = 1.8 nM).1 It is selective for integrin α4β1 over the integrins α4β7, α9β1, and α2β1 (IC50s = >500, 138, and 1,053 nM, respectively). BIO-5192 (1 µg/ml) inhibits the adhesion of α4β1-expressing A20 cells to fibronectin-coated plates.2 It improves limb function in a rat model of experimental autoimmune encephalomyelitis (EAE) induced by myelin basic protein (MBP) peptide when administered at a dose of 30 mg/kg twice per day.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Leone, D.R., Giza, K., Gill, A., et al. An assessment of the mechanistic differences between two integrin α4β1 inhibitors, the monoclonal antibody TA-2 and the small molecule BIO5192, in rat experimental autoimmune encephalomyelitis. J. Pharmacol. Exp. Ther. 305(3), 1150-1162 (2003).

    2. Ramirez, P., Rettig, M.P., Uy, G.L., et al. BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells. Blood 114(7), 1340-1343 (2009).