A MNK1 inhibitor
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DS12881479

Item No. 44121

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-methyl-N-(5-phenyl-2-thiazolyl)-4-piperidinecarboxamide
CAS Number
2373065-59-7
Molecular Formula
C16H19N3OS
Formula Weight
301.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
CN1CCC(C(NC(S2)=NC=C2C3=CC=CC=C3)=O)CC1
InChi Code
InChI=1S/C16H19N3OS/c1-19-9-7-13(8-10-19)15(20)18-16-17-11-14(21-16)12-5-3-2-4-6-12/h2-6,11,13H,7-10H2,1H3,(H,17,18,20)
InChi Key
BTZKRRFKIKIADV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $127

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    5 mg

    $506

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    10 mg

    $823

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    25 mg

    $1,424

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    Product Description

    DS12881479 is an inhibitor of MAP kinase-interacting serine/threonine protein kinase 1 (MNK1; IC50s = 21 and 416 nM for the inactive and active forms, respectively).1 It is selective for MNK1 over 46 other kinases but does inhibit FMS-related tyrosine kinase 3 (FLT3) and dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) at 5 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Matsui, Y., Yasumatsu, I., Yoshida, K.I., et al. A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1. Acta Crystallogr. F Struct. Biol. Commun. 74(Pt. 3), 156-160 (2018).