Active • Host: HEK293 cells • AA: 20-512 • MW: 54.5 kDa
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CSF-1R/CD115 (human, recombinant)

Item No. 44181

Product Insert (PDF)
Technical Information
Synonyms
  • c-Fms
  • FIM2
  • FMS
  • HDLS
  • Macrophage Colony-stimulating Factor 1 Receptor
  • McDonough Feline Sarcoma Viral Oncogene Homolog
  • MCSF-1 Receptor
Purity
≥90% as estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU EU/µg, as determined by the LAL endotoxin assay
Source
Active recombinant huma CSF-1R expressed in HEK293 cells
Amino Acids
20-512
MW
54.5 kDa
Formulation (Request formulation change)
Lyophilized from sterile PBS, pH 7.4
Host
HEK293 cells
UniProt Accession №
P07333
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µg

    $298

    Add

    1 mg

    $1,043

    Add
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    Product Description

    Colony-stimulating factor 1 receptor (CSF-1R), also known as CD115, is a single-pass transmembrane protein encoded by CSF1R, previously known as the c-fms proto-oncogene, in humans.1 It is composed of a glycosylated extracellular domain containing ligand-binding and dimerization regions, a transmembrane domain, and an intracellular tyrosine kinase domain. CSF-1R is expressed in monocytes, macrophages, osteoclasts, and microglia, among other cell types.2 Upon binding by CSF-1R or IL-34, CSF-1R dimerizes and is autophosphorylated leading to ERK1/2, AMPK, Src/FAK, or Akt signaling.3,4 In this way, CSF-1R is involved in a wide variety of processes, including osteoclast cytoskeletal remodeling, macrophage motility, proliferation, and survival, and microglial proliferation.2,3,4 Increased intratumoral expression of CSF1R is associated with multiple cancer types and is predictive of poor prognosis in hematological cancers.5 Cayman’s CSF-1R/CD115 (human, recombinant) protein can be used for binding assays. This protein consists of 493 amino acids and has a calculated molecular weight of 54.5 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 100 kDa due to glycosylation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yeung, Y.-G., and Stanley, E.R. Proteomic approaches to the analysis of early events in colony-stimulating factor-1 signal transduction. Mol. Cell Proteomics 2(11), 1143-1155 (2003).

    2. Mun, S.H., Park, P.S.U., and Park-Min, K.-H. The M-CSF receptor in osteoclasts and beyond. Exp. Mol. Med. 52(8), 1239-1254 (2020).

    3. Pixley, F.J., and Stanley, E.R. CSF-1 regulation of the wandering macrophage: complexity in action. Trends Cell Biol. 14(11), 628-638 (2004).

    4. Freuchet, A., Salama, A., Remy, S., et al. IL-34 and CSF-1, deciphering similarities and differences at steady state and in diseases. J. Leukoc. Biol. 110(4), 771-796 (2021).

    5. Mo, H., Hao, Y., Lv, Y., et al. Overexpression of macrophage-colony stimulating factor-1 receptor as a prognostic factor for survival in cancer: A systematic review and meta-analysi. Medicine (Baltimore) 100(12), e25218 (2021).