Host: HEK293 cells • AA: 19-416 • Tag: C-terminal His • MW: 45.7 kDa
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

DDR1b Extracellular Domain (human, recombinant)

Item No. 44194

Product Insert (PDF)
Technical Information
Synonyms
  • CD167
  • CD167 Antigen-like Family Membe
  • DDR1 Isoform b
  • Discoidin Domain-containing Receptor 1b
  • Discoidin Domain-containing Receptor Tyrosine Kinase 1b
  • Discoidin Domain Receptor 1b
Purity
≥97% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU per g of the protein as determined by the LAL method
Source
Recombinant human C-terminal His-tagged DDR1b expressed in HEK293 cells
Amino Acids
19-416
MW
45.7 kDa
Formulation (Request formulation change)
Lyophilized from sterile PBS, pH 7.4
UniProt Accession №
Q08345
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µg

    $298

    Add

    1 mg

    $1,937

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    Discoidin domain-containing receptor 1 (DDR1), also known as CD167, is a receptor tyrosine kinase (RTK) with roles in cell migration, proliferation, and differentiation and other physiological and pathological processes regulated by collagen remodeling.1,2 It is composed of an extracellular discoidin domain, a transmembrane domain, and intracellular juxtamembrane and kinase domains.2 DDR1 is selectively expressed in epithelial cells and localizes to the cell membrane.3 DDR1 undergoes alternative splicing to produce five isoforms, of which three, DDR1a, DDR1b, and DDR1c, are kinase active and two, DDR1d and DDR1e, are kinase domain-deficient. Unlike most RTKs that bind soluble ligands, DDR1 binds to and is activated by fibrillar and non-fibrillar collagens. DDR1b binds directly to talin and enhances integrin β1-mediated cell migration.1 Cayman's DDR1b Extracellular Domain (human, recombinant) protein consists of 409 amino acids, has a calculated molecular weight of 45.7 kDa, and a predicted N-terminus of Asp19 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 55-60 kDa due to glycosylation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Borza, C.M., Bolas, G., Zhang, X., et al. The collagen receptor discoidin domain receptor 1b enhances integrin β1-mediated cell migration by interacting with talin and promoting Rac1 activation. Front. Cell Dev. Biol. 10, 836797 (2022).

    2. Tian, Y., Bai, F., and Zhang, D. New target DDR1: A "double-edged sword" in solid tumors. Biochim. Biophys. Acta Rev. Cancer 1878(1), 188829 (2023).

    3. Song, S., Shackel, N.A., Wang, X.M., et al. Discoidin domain receptor 1: Isoform expression and potential functions in cirrhotic human liver. Am. J. Pathol. 178(3), 1134-1144 (2011).