A histamine H1 receptor antagonist
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Tripelennamine (hydrochloride)

Item No. 44223

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-dimethyl-N-(phenylmethyl)-N-2-pyridinyl-1,2-ethanediamine, monohydrochloride
CAS Number
154-69-8
Synonyms
  • NIH 10186
Molecular Formula
C16H21N3 • HCl
Formula Weight
291.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
CN(C)CCN(CC1=CC=CC=C1)C2=NC=CC=C2.Cl
InChi Code
InChI=1S/C16H21N3.ClH/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15;/h3-11H,12-14H2,1-2H3;1H
InChi Key
FSSICIQKZGUEAE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $83

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    1 g

    $132

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    5 g

    $495

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    10 g

    $825

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    Product Description

    Tripelennamine is a histamine H1 receptor antagonist (Ki = 7.4 nM).1 It is selective for the histamine H1 receptor over muscarinic acetylcholine receptors (mAChRs; Ki = 1,300 nM). Tripelennamine also selectively inhibits histamine- over acetylcholine-induced contractions in isolated guinea pig ileum segments (EC50s = 14 and 7,800 nM, respectively), as well as serotonin-induced contractions in isolated rat uterus (EC50 = 14,000 nM).2 It protects against histamine-induced lethality and dyspnea in guinea pigs with half-maximal protective dose (PD50) values of 2.74 and 1.2 mg/kg, respectively. Formulations containing tripelennamine have been used as antihistamines in veterinary medicine.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kubo, N., Shirakawa, S., Kuno, T., et al. Antimuscarinic effects of antihistamines: Quantitative evaluation by receptor-binding assay. Jpn. J. Pharmacol. 43(3), 277-282 (1987).

    2. Tozzi, S., Roth, F.E., and Tabachnick, I.I.A. The pharmacology of azatadine, a potential antiallergy drug. Agents Actions 4(4), 264-270 (1974).