An ACC inhibitor
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Olumacostat Glasaretil

Item No. 44262

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(tetradecyloxy)-2-furancarboxylic acid, 2-[(2-ethoxy-2-oxoethyl)methylamino]-2-oxoethyl ester
CAS Number
1261491-89-7
Synonyms
  • DRM01
Molecular Formula
C26H43NO7
Formula Weight
481.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C1=CC=C(OCCCCCCCCCCCCCC)O1)OCC(N(CC(OCC)=O)C)=O
InChi Code
InChI=1S/C26H43NO7/c1-4-6-7-8-9-10-11-12-13-14-15-16-19-32-25-18-17-22(34-25)26(30)33-21-23(28)27(3)20-24(29)31-5-2/h17-18H,4-16,19-21H2,1-3H3
InChi Key
FYJLDICZGDFWKP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $65

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    10 mg

    $117

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    25 mg

    $228

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    50 mg

    $390

    Add
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    Product Description

    Olumacostat glasaretil is an inhibitor of acetyl-CoA carboxylase (ACC).1 It increases the ratio of acetyl-CoA to free CoA in hamster ear sebaceous glands when applied topically at a concentration of 6% (w/w). Olumacostat glasaretil (0.3, 1, or 3 µM) inhibits triacylglycerol formation induced by T0901317 (Item No. 71810) and insulin in primary human sebocytes. It decreases hamster ear sebaceous gland lipid area when applied topically at a concentration of 6% (w/w) twice per day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hunt, D.W., Winters, G.C., Brownsey, R.W., et al. Inhibition of sebum production with the acetyl coenzyme A carboxylase inhibitor olumacostat glasaretil. J. Invest. Dermatol. 137(7), 1415-1423 (2017).