A FFAR1/GPR40 agonist
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TUG-469

Item No. 44272

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[(2′-methyl[1,1′-biphenyl]-3-yl)methyl]amino]-benzenepropanoic acid
CAS Number
1236109-67-3
Molecular Formula
C23H23NO2
Formula Weight
345.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(CCC1=CC=C(NCC2=CC(C3=C(C)C=CC=C3)=CC=C2)C=C1)O
InChi Code
InChI=1S/C23H23NO2/c1-17-5-2-3-8-22(17)20-7-4-6-19(15-20)16-24-21-12-9-18(10-13-21)11-14-23(25)26/h2-10,12-13,15,24H,11,14,16H2,1H3,(H,25,26)
InChi Key
RUPXKSLKGSSZCP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $28

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    25 mg

    $52

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    50 mg

    $97

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    100 mg

    $180

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    TUG-469 is an agonist of free fatty aid receptor 1 (FFAR1/GPR40).1 It induces calcium mobilization in a reporter assay using cells expressing human FFAR1/GPR40 (EC50 = 18.6 nM). TUG-469 (10 µM) induces insulin secretion in INS-1E insulinoma cells. It inhibits increases in blood glucose levels in a glucose tolerance test (GTT) in mice when administered at a dose of 5 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Christiansen, E., Due-Hansen, M.E., Urban, C., et al. Structure-activity study of dihydrocinnamic acids and discovery of the potent FFA1 (GPR40) agonist TUG-469. ACS Med. Chem. Lett. 1(7), 345-349 (2010).

    2. Urban, C., Hamacher, A., Partke, H.J., et al. In vitro and mouse in vivo characterization of the potent free fatty acid 1 receptor agonist TUG-469. Naunyn Schmiedebergs Arch Pharmacol. 386(12), 1021-1030 (2013).