An IRAK4 inhibitor
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Edecesertib

Item No. 44286

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[(1R)-1-cyanoethyl]amino]-6-(3-cyanopyrrolo[1,2-b]pyridazin-7-yl)-N-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl]-3-pyridinecarboxamide
CAS Number
2408839-73-4
Synonyms
  • GS-5718
Molecular Formula
C22H22FN7O2
Formula Weight
435.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
N#C[C@@H](C)NC1=C(C(NC[C@H](C(C)(C)O)F)=O)C=NC(C2=CC=C3N2N=CC(C#N)=C3)=C1
InChi Code
InChI=1S/C22H22FN7O2/c1-13(8-24)29-17-7-18(19-5-4-15-6-14(9-25)10-28-30(15)19)26-11-16(17)21(31)27-12-20(23)22(2,3)32/h4-7,10-11,13,20,32H,12H2,1-3H3,(H,26,29)(H,27,31)/t13-,20-/m1/s1
InChi Key
HORBHQPSWJRDSV-ZUOKHONESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $127

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    5 mg

    $601

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    10 mg

    $950

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    25 mg

    $2,056

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    Product Description

    Edecesertib is an inhibitor of IL-1 receptor-associated kinase 4 (IRAK4; IC50 = 0.6 nM).1 It is selective for IRAK4 over a panel of 484 additional kinases at 1,000 nM. Edecesertib inhibits toll-like receptor 7 (TLR7) agonist-induced IFN-α production in isolated human whole blood (IC50 = 124 nM). Dietary administration of edecesertib (0.07% w/w in chow) reduces proteinuria and decreases plasma levels of TNF-α and IL-12 in an NZBWF1 mouse model of systemic lupus erythematosus (SLE).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ammann, S.E., Cottell, J.J., Wright, N.E., et al. Discovery of edecesertib (GS-5718): A potent, selective inhibitor of IRAK4. J. Med. Chem. 68(11), 10619-10630 (2025).