An Aurora A kinase inhibitor
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JAB-2485

Item No. 44291

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(3-chloro-2-fluorophenyl)methyl]-4-[[5-fluoro-4-methyl-6-[(3-methyl-1H-pyrazol-5-yl)amino]-2-pyridinyl]methyl]-2-methyl-4-piperidinecarboxylic acid
CAS Number
2899209-55-1
Molecular Formula
C25H28ClF2N5O2
Formula Weight
504.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/ml
SMILES
FC(C(Cl)=CC=C1)=C1CN2CC[C@](C(O)=O)(CC3=CC(C)=C(F)C(NC4=CC(C)=NN4)=N3)C[C@H]2C
InChi Code
InChI=1S/C25H28ClF2N5O2/c1-14-9-18(29-23(21(14)27)30-20-10-15(2)31-32-20)12-25(24(34)35)7-8-33(16(3)11-25)13-17-5-4-6-19(26)22(17)28/h4-6,9-10,16H,7-8,11-13H2,1-3H3,(H,34,35)(H2,29,30,31,32)/t16-,25-/m1/s1
InChi Key
CEONSWRDFKMFNM-PUAOIOHZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $215

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    5 mg

    $644

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    Product Description

    JAB-2485 is an inhibitor of Aurora A kinase (IC50 = 0.327 nM).1 It is selective for Aurora A over Aurora B and Aurora C kinases at 2 µM. JAB-2485 decreases levels of phosphorylated Aurora A kinase in NCI H446 small-cell lung cancer cells (IC50 = 2.08 nM) and reduces the viability of 11 lung cancer cell lines (IC50s = 29.7-982 nM). JAB-2485 (0.3, 1, and 3 µM) induces apoptosis and cell cycle arrest at the G2/M phase in NCI H446 cells. It decreases tumor volume without affecting body weight in an NCI H446 mouse xenograft model when administered at doses of 10 or 20 mg/kg per day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, G., Lin, Y., Sun, X., et al. Preclinical evaluation of JAB-2485, a potent AURKA inhibitor with high selectivity and favorable pharmacokinetic properties. ACS Omega 9(19), 21416-21425 (2024).